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Intro
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Classroom Contents
Antibiotic Bootcamp - What Makes a Good Hit - Why and How Do You Write a TPP
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- 1 Intro
- 2 Short Talks
- 3 Discovery Strategies
- 4 Hit Generation
- 5 Mechanism of Action
- 6 Evaluate the Pharmacology
- 7 What Did You Scream
- 8 What Was Your Screening Cell
- 9 Big Pharma Sample Collection
- 10 Libraries for Hire
- 11 Fuzzy Data
- 12 False Positives
- 13 Real Positives
- 14 The Right Way
- 15 Triage
- 16 Chemist
- 17 How much money
- 18 Common structures
- 19 Pains
- 20 Rhodamine
- 21 Computational Filters
- 22 Backlash
- 23 Structure Activity Relationship
- 24 Optimization
- 25 Increasing potency
- 26 Tractable lead
- 27 Properties
- 28 The Rule of Five
- 29 Drug Like
- 30 Lipinsky Space
- 31 Bulking Up
- 32 Natural Products
- 33 Is it good enough
- 34 Lipinski defined drug
- 35 Lipinski definition of drug
- 36 Gram positive drugs
- 37 Gram negative drugs
- 38 What is gram negative antibacterial
- 39 What is a good hit
- 40 Small molecules
- 41 Property space
- 42 Hergenrother
- 43 Lipinsky Parameters
- 44 Running through an example
- 45 Optimization parameters
- 46 Pharmacokinetics
- 47 Therapeutic Index
- 48 Chemical Design
- 49 Physical Properties
- 50 Medicinal Chemistry
