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edX

Hibernation Science

University of Alaska Fairbanks via edX

Overview

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Hibernation science considers the ways different animals hibernate, and while there is some evidence that early humans may have hibernated to survive the winter months, most consider true human hibernation the stuff of science fiction. However, scientists are working on moving this concept from sci-fi imaginings to reality. Through interactive activities, comparative analysis and creative problem-solving, this course will cover topics that include:

  • Hibernation Mechanisms: the physiological processes of hibernation, including metabolic suppression, thermoregulation (body temperature), and resistance to muscle and bone loss in species like bears, arctic ground squirrels, and wood frogs.

  • Challenges of Human Hibernation: barriers to replicating hibernation in human bodies, such as managing glucose homeostasis and metabolic rates, cardiovascular adaptations (heart rate), and sensory deprivation, and discussing potential solutions.

  • Applications to Space Travel: how traits from hibernating animals can address challenges like radiation exposure, isolation, and lean mass preservation during long-distance or deep space missions and long periods of space exploration.

Syllabus

Week 1 - Welcome to Hibernation Science!

  • Introduction to the feasibility and risks of long-term space travel and how animal models can be used to advance hibernation-like states for humans.
  • Examine the physiological mechanisms that enable wood frogs and other ectotherms to survive in extreme cold through interactive experiments, demonstrations, and videos.
  • Explore the challenges humans face in achieving cryogenic preservation, contrasting human biology with that of freeze-tolerant species, such as wood frogs.
  • Introduction to the science of hibernation for arctic ground squirrels who survive and thrive in extreme environmental challenges.

Week 2 - Hibernation and Beyond!

  • Examine the mechanisms and challenges of inducing synthetic torpor using arctic ground squirrels as a model to explore potential applications for medical and space travel scenarios.
  • Explore the unique hibernation strategies of black bears that enable them to manage challenges such as isolation, radiation, and hostile environments, with implications for human adaptation to extreme conditions.
  • Investigate the physiological barriers to humans replicating bear hibernation while exploring how bears uniquely maintain health during prolonged inactivity.
  • Evaluate and debate which adaptations best address the challenges of space travel, culminating in a creative activity to design an ideal hibernator, followed by a course wrap-up and conclusion.

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