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Massachusetts Institute of Technology

Cell Biology: Signaling

Massachusetts Institute of Technology via edX


This is the second cell biology course in a four-part series. Building upon the concepts from biochemistry, genetics, and molecular biology from our 7.00x Introductory Biology and 7.05x Biochemistry MOOCs, these cell biology courses transition to a comprehensive discussion of biology at an experimental level. How do we know what we know about cells at a molecular level and how can we use that knowledge to design experiments to test hypotheses in cell biology?

Professors Iain Cheeseman and Frank Solomon guide you through a learning experience where you will discover experiments that answered big questions and find out what is still on the horizon. You will embark on a lively journey through cellular signaling mechanisms, regulation, and specific examples and learn how to apply key concepts and themes of this dynamic experimental science to understand the fundamental workings of cells.

We developed the 7.06x Cell Biology series with an emphasis on:

  • Developing your scientific thinking skills including articulating hypotheses, performing thought experiments, interpreting data, and designing experiments.

  • Using data based on real scientific experiments and highlighting the scientific process in assessments.

  • Asserting that biology is an active field that changes daily through examples of research and relevance to medicine, not static information in a textbook.

  • Uniting themes and principles that inform how scientists conduct and interpret research.

  • Exploring foundational “neat experiments” that defined modern cell biology.

  • Implementing the science of learning in the course design.


  • Principles of Signal Transduction
  • Specific Signaling Pathways
  • Regulatory Paradigms
  • Unfolded Protein Response

Taught by

Iain Cheeseman, Frank Solomon, Mary Ellen Wiltrout, Darcy Gordon and Monika Avello

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  • Another great course in MIT's bio series. Primarily the course covers various signaling pathways: G-proteins, which send second messengers out to start cascades; various pathways that use dimerization and autophosphorylation to start a signal; and...

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