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University of Pennsylvania

Experimental Genome Science

University of Pennsylvania via Coursera


Each of our cells contains nearly identical copies of our genome, which provides instructions that allow us to develop and function. The field of Genomics focuses on the structure and function of genomes and plays a major and increasing role in both medicine and research. This course serves as an introduction to the main laboratory and theoretical aspects of genomics and is divided into themes: genomes, genetics, functional genomics, systems biology, single cell approaches, proteomics, and applications. We start with the basics, DNA sequencing and the genome project, then move to high throughput sequencing methods and applications. Next we introduce principles of genetics and then apply them in clinical genetics and other large-scale sequencing projects. In the functional genomics unit, we start with RNA expression dynamics, analysis of alternative splicing, epigenomics and ChIP-seq, and metagenomics. Model organisms and forward and reverse genetics screens are then discussed, along with quantitative trait locus (QTL) and eQTL analysis. After that, we introduce integrative and single cell genomics approaches and systems biology. Finally, we conclude by introducing in applying proteomic approaches.

Taught by

John Hogenesch and John Isaac Murray


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3.0 rating, based on 3 reviews

Start your review of Experimental Genome Science

  • Anonymous

    Anonymous completed this course.

    In the description of this course you could read: "We start with the basics, DNA sequencing and the genome project, then move to high throughput sequencing methods and applications". If you are assuming that all this concepts will be explained, then you are wrong. Is just the opposite. The course starts assuming that you are already well versed on these themes. Before taken this course, you have to know a lot of molecular biology.
  • Anonymous

    Anonymous completed this course.

    Too many written assignments. Boring and not well put together. Just take a writing class instead.
  • Anonymous

    Anonymous completed this course.

    Not a beginners course at all. Graduate student level for computational and experimental genomics.

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