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Principles and Applications of NMR Spectroscopy

Indian Institute of Science Bangalore via NPTEL

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Overview

The objective of the course is to teach the basic aspects of nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical tool in chemical and pharmaceutial industry for structural characterization of molecules.
The topics to be covered will include one-dimensional NMR, Chemical shifts, J-coupling, Interpretation of 1D NMR spectrum, Basics of 2D NMR, Different 2D NMR experiments and their application/interpretation, Application of 2D NMR for assignment of molecules and peptides.

Syllabus

Week 1:
Introduction to NMR spectroscopy

Week 2:
Chemical shifts and J-coupling

Week 3:
One-dimensional proton NMR

Week 4:
One dimensional NMR of X-nuclei (13C, 15N, 31P and 19F)

Week 5:
Homonuclear 2D NMR

Week 6:
Heteronucler 2D NMR

Week 7:
Structure determination of molecules

Week 8:
Advanced topics (Solvent suppression, Drug Discovery, DOSY)

Taught by

H. S. Atreya

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