Warning: this course contains shocking materials and is not recommended for viewing to persons with weak psyche, minors and pregnant women.
The course describes subject and methods of Pathophysiology, its place within system of biomedical sciences and history. It includes General Nosology (concept of health and disease, general etiology and pathogenesis, pathological processes and states, role of causal factors, conditions, reactivity and somatotype in pathology). It gives systematic of locally and centrally driven typical pathological processes: arterial, venous and combined hyperemiae, stasis, inflammation, immunopathological processes (including allergy and autoimmune disorders) acute phase response, fever, stress, shock, etc. Course deals with functional, metabolic and informational aspects of typical pathologic processes, like disorders of signaling, reception, post – receptor translation, programming and program archiving, conflicts of programs in living systems. It contains the consequent analysis of the injury and defensive responses as regards separate cells, organs and tissues and the whole organism. The lectures based on author’s original three-volumed textbook and workshop in Pathophysiology republished in Russia many times.
Pathophysiology as a Science
General Nosology. Health and Disease
Aetiological doctrines: monocausalism, conditionalism and constitutionalism
Locally driven typical pathological processes. Pathophysiology of microcirculation
This course is perhaps among a small number of medically oriented Coursera offerings that go beyond a comfortable introduction on a certain topic. I can argue that the material can serve as a good substitute for the first few weeks of a medical school...
This course is perhaps among a small number of medically oriented Coursera offerings that go beyond a comfortable introduction on a certain topic. I can argue that the material can serve as a good substitute for the first few weeks of a medical school pathology course. For someone who unfortunately did not pay good attention to his own pathology classes, this course is an excellent refresher especially for foundational topics – those that are often assumed to be fully understood as they are mentioned in passing whenever specific diseases are discussed. That being said, I think this particular offering can easily alienate those with little to no basic or applied background in pathophysiology. The historical context for the highlighted is strongly emphasized throughout the material (the first half being almost entirely about history) – a feature that I appreciate highly, as it shows (1) the evolution of our collective scientific understanding of pathophysiologic phenomena and (2) that science does not always get it right the first time.
My only major disappointment in the course is that some of the weekly quiz questions seem to be misplaced, as the lectures covering them are found in the following weeks. Furthermore, some modified multiple choice and non-multiple choice questions are frustratingly difficult to answer even with several repeat attempts, which I hope will be addressed on future revisions. Future iterations of this course should expand the current second half of the material which deals with the “real meat” of general pathophysiology as it presently stands. Nevertheless, this course is highly recommended for students and practitioners of biology- and/or medicine-related basic and applied sciences.