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Indian Institute of Technology Madras

Bioreactor Design and Analysis

Indian Institute of Technology Madras and NPTEL via Swayam


This is a core course suitable for undergraduate or postgraduate students interested in the area of bioprocess engineering or biological engineering. The course introduces the student to design principles of batch, fed-batch and continuous bioreactors. Mass and heat transfer requirements for a given fermentation system will be discussed. The student will also be able to identify suitable criterion for the scale-up of bioprocesses and characterize non-ideality in bioreactors, if present. INTENDED AUDIENCE:Students with a background in Biotechnology/ Bioprocess Engineering/Biochemical Engineering/Chemical EngineeringPREREQUISITES:The student is expected to have a basic knowledge of mathematics Prerequisite courses can be Material and Energy Balances, Biological Rate processes, Enzyme science and EngineeringINDUSTRIES SUPPORT:All biotechnology based/fermentation Industries. SMEs/Companies dealing with production of compounds via microbial/plant/animal cell fermentations


Week 1: Introduction to the courseWeek 2: Design of batch bioreactorsWeek 3: Design of fed-batch bioreactorsWeek 4: Design of continuous mode of bioreactorsWeek 5: Mass transfer in bioreactors, Rheology of fermentation broths, Heterogeneous reactions in bioprocessesWeek 6: Heterogeneous reactions in bioprocesses (contd.), Heat transfer in bioreactorsWeek 7: Heat transfer in bioreactors (contd.) Scale-up of bioreactors: criteria for scale-up, scale-up parametersWeek 8: Scale-up of bioreactors (contd.), Non-ideal reactors: design and analysis

Taught by

Prof. Smita Srivastava

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