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Indian Institute of Technology Madras

Biostatistics and Design of experiments

Indian Institute of Technology Madras and NPTEL via Swayam


Biostatistics is the application of statistics to different topics in biology including medicine, pharmacy, public health science, agriculture and fishery. It involves the analysis of data from experiments; its interpretation and drawing conclusion from the results. It is very relevant to all UG and PG level degree programmes majoring in Biotechnology and allied fields as well as practicing scientists. It involves the application of statistical theory to real-world problems, the practice of designing and conducting biomedical experiments and clinical trials. Design of experiments is planning experimental strategy, screening a large number of parameters and selecting the important ones, determining the minimum number of experiments and deciding on the mode and manner in which experiment have to be conducted. The course encompasses topics such as distribution of data, sample size, tests of significance, data reduction, regression analysis, comparison of performance of drugs in clinical trials, design of experiments, screening and second order designs.INTENDED AUDIENCE :UG/PG Biotech programmes (core or elective) and research scientists in biotechnology, clinical trials, agriculture etc and allied fieldsPREREQUISITES :Basics of probability and statisticsINDUSTRY SUPPORT :Biopharma, Agriculture, fisheries and Biotechnology companies.


Module 1
Experimental design strategy
Data types/Binomial Distribution
Poisson Distribution
Normal Distribution

Module 2
Standardized Normal Distribution/ t distribution
t distribution/confidence interval
Statistical tests
t- tests
t- tests – continued

Module 3

t- tests – continued
F- tests
F- tests –continued

Module 4

Module 5

c2 distribution/test
c2 distribution/test –continued
c2 test
Weibull distribution

Module 6
Weibull distribution-contniued
Weibull distribution-continued
Nonparametric tests
Nonparametric tests/Homogeneity of variance/Beta distribution
Exponential / Hypergeometric distributions

Module 7
Hypergeometric/Log normal distributions
Design of Experiments (DOE) – Introduction
Factorial design
Full Factorial design
Fractional Factorial design

Module 8
Other designs
Second order designs
Second order designs-continued
Regression Analysis Control Charts

Taught by

Mukesh Doble


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