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Multidimensional NMR Spectroscopy for Structural Studies of Biomolecules

Indian Institute of Science Bangalore and NPTEL via Swayam


The objective of the course is to introduce methods used in NMR spectroscopy for structure determination of biomolecules and for studying protein-ligand interactions. The course will cover principles and application of two- and three-dimensional NMR experiments along with different isotope labelling schemes that are routinely used for protein structure determination.

M. Sc/Ph. D students, Scientists from Pharma/Biotech Companies

PREREQUISITES: 1. Mathematics at the 12th Std level,2. Basic Knowledge of Proteins/Nucleic Acids,3. A basic knowledge of NMR would be useful,though not necessary


Week 1  :  Introduction to Basics of NMR
Week 2  :  Two dimensional NMR
Week 3  :  Important 2D NMR experiments for Biomolecules
Week 4  :  3D NMR Spectroscopy
Week 5  :  Basics of Protein and Nucleic Acid Structure
Week 6  :  Isotope Labelling
Week 7  :  Resonance assignment of Proteins with NMR and Structure Determination
Week 8  :  NMR Experiments for Studying Protein-Ligand Interactions

Taught by

Prof. Hanudatta S. Atreya

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