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Indian Institute of Technology, Kharagpur

Organic Chemistry in Biology and Drug Development

Indian Institute of Technology, Kharagpur and NPTEL via Swayam

Overview

In the biosphere, the chemistry must be considered in the context of the cell, or an organ, or even a whole organism. That makes mimicking of biological processes to be extremely challenging as the reaction needs to be performed with perfect orthogonality to other functional entities present in a biological system. Today, with the advancement of various spectroscopic and molecular biology techniques and with a better understanding of chemical principles, functions of various bio molecules have been unravelled which has paved the way for development of newer drugs. The present course is an attempt to bridge the gap in our understanding of biological systems and processes at the molecular and functional level. The course first introduces the various kinds of bio molecules, macro to medium size to small, their structures and functions followed by molecular engineering to manipulate their activity and biosynthesis. That creates a perfect platform for the next module on drug design and discoveryINTENDED AUDIENCE : Chemistry, Biochemistry, Chemical Biology, Pharmacy Students/facultyPREREQUISITES : Basic Organic Chemistry

Syllabus

Week 1 : Introduction,Amino Acids,Peptides and proteinsWeek 2 : Peptides and proteins (contd.)Week 3 : Peptides and proteins (contd.)Week 4 : Proteins as biological catalyst,Concept of inhibitionWeek 5 : Nucleic acids,Week 6 : Metabolism,Synthetic biology,Molecular BiologyWeek 7 : Chemistry of cofactors/coenzymesWeek 8 : Principle of drug design,Modern day drug discoveryWeek 9 : Chemistry of diseases and Drug developmentWeek 10: Chemistry of diseases and Drug development (contd.)Week 11: Proton pump inhibitors,Gene replacement and deliveryWeek 12: Revision and Problem solving

Taught by

Prof. Amit Basak

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