This introductory virology course explores the interplay between viruses and their host organisms. The course begins with an overview of how infection is established in a host, then moves to a virologist's view of immune defenses. Next we consider how the replication strategy and the host response determine the outcome of infection, such that some are short and others are of long duration. The mechanisms by which virus infections transform cells in culture are explored, a process that may lead to tumor formation in animals. We then move to a discussion of how viral infections are controlled by vaccines and antiviral drugs. After an introduction to viral evolution, we discuss the principles learned from zoonotic infections, emerging infections, and humankind's experiences with epidemic and pandemic viral infections. The course ends with an exploration of unusual infectious agents such as viroids, satellites, and prions, followed by a discussion of the causative agent of the most serious current worldwide epidemic, HIV-1.
Week 1 Infection basics Entry into the host Viral spread Tissue invasion and tropism Transmission and seasonality
Week 2 Innate immune responses Interferon Sentinels and complement Inflammation Adaptive immunity
Week 3 Viral virulence Mechanisms of cell injury I Mechanisms of cell injury II Host susceptibility
Week 4 Acute infections Influenza Poliomyelitis Measles Gastroenteritis West Nile fever
Week 5 Persistent infections Persistence by modulating the adaptive response Two persistent infections Herpes simplex virus Epstein-Barr virus
Week 6 Transformation RNA tumor viruses Transforming retroviruses DNA tumor viruses Epiphenomena of a unique life styleWeek 7 Vaccines How do you make a vaccine? Inactivated vaccines Attenuated vaccines
Week 8 Antivirals Antiviral discovery Antiviral resistance Other antiviral targets HIV antivirals
Week 9 Viral evolution Drivers of evolution Error threshold and bottlenecks Selection Origins of viruses
Week 10 Emerging viruses Host-virus interactions Examples of emerging viruses SARS and MERS Canine parvovirus
Week 11 Viroids Satellites Transmissible spongiform encephalopathies Prions
Week 12 HIV and AIDS The origin of HIV HIV pathogenesis An amazing but deadly virus
Tg is taking this course right now, spending 6 hours a week on it and found the course difficulty to be medium.
Best ever ! Interesting updated accessible
Well built examples for all!
Recommend to every student and lab technician. May you return the course to coursera. Since I really want to re enroll
John Smith completed this course, spending 3 hours a week on it and found the course difficulty to be hard.
Extremely interesting course, one of my favorites. Sometimes the content is a bit too detailed, since you are expected to know some particular genes and acronyms. However, it's completely worth it, and the challenge is fun rather than frustrating.