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Beijing Institute of Technology

化学生物学

Beijing Institute of Technology via XuetangX

Overview






I am Yang Yu from Beijing Institute of Technology. Welcome to the exciting world of Chemical Biology, a dynamic and interdisciplinary field at the intersection of chemistry and biology. Our course is designed to immerse you in the principles, techniques, and groundbreaking research that drive this rapidly evolving discipline.

Chemical Biology is a frontier science that explores the chemical principles underlying biological processes. By understanding these principles, we can manipulate biological systems to develop new therapies, discover novel biochemical pathways, and create innovative technologies. This course is perfect for students who are passionate about both chemistry and biology and are eager to apply their knowledge to solve real-world problems.

In this course, you will learn

Chemical Synthesis of Biomolecules: Learn how to chemically synthesize and modify nucleic acids, proteins, and other biomolecules.

Tools of chemical biology, including Bioorthogonal Reactions, Genetic Code Expansion, chemical genetics, protein structure prediction, and protein design.

Applications in Medicine and Biotechnology: Study the practical applications of chemical biology in the development of new drugs, new therapies, and new biotechnology tools.

Welcome to the world of Chemical Biology!


大家好,我是来自北京理工大学的于洋。欢迎来到令人兴奋的化学生物学世界,这是一个充满活力的跨学科领域,位于化学和生物学的交叉点。我们的课程旨在让您沉浸在推动这一快速发展学科的原理、技术和开创性研究中。

化学生物学是一门前沿科学,探索生物过程背后的化学原理。通过理解这些原理,我们可以操纵生物系统来开发新疗法,发现新的生化途径并创造创新技术。这门课程非常适合对化学和生物学充满热情并渴望运用他们的知识解决现实问题的学生。

在本课程中,您将学习

生物分子的化学合成:学习如何化学合成和修饰核酸、蛋白质和其他生物分子。

化学生物学工具,包括生物正交反应、遗传密码扩展、化学遗传学、蛋白质结构预测和蛋白质设计。

在医学和生物技术中的应用:研究化学生物学在开发新药、新疗法和新生物技术工具中的实际应用。

欢迎来到化学生物学的世界!



Syllabus

  • 1. Introduction
    • 1.1 Introduction to Chemical Biology
    • 1.2 Exercises
  • 2. Peptide and protein
    • 2.1 Peptides and Proteins
    • 2.2 Chemical synthesis of protein
    • 2.3 Exercises
  • 3. Nucleic acid
    • 3.1 Nucleic Acids
    • 3.2 Interaction of nucleic acid with other molecules
    • 3.3 Exercises
  • 4. genetic codon expansion
    • 4.1 Unnatural Amino Acid
    • 4.2 Application of UAAs
    • 4.3 Exercises
  • 5. Chemical biology of carbohydrates
    • 5.1 Structure and function of carbohydrates
    • 5.2 Chemical synthesis of carbohydrates
    • 5.3 Chemical probes for carbohydrate metabolism
    • 5.4 Exercises
  • 6. Evolution of bio-macromolecules
    • 6.1 Evolution of bio-macromolecules in nature
    • 6.2 Applications of bio-macromolecule evolution
    • 6.3 Exercises
  • 7. Protein structure prediction
    • 7.1 Protein folding and structure prediction
    • 7.2 AI-based structure prediction
    • 7.3 Exercises
  • 8. Protein Design
    • 8.1 Folding and protein computational design
    • 8.2 AI-based protein design
    • 8.3 Exercises
  • 9. Organic molecules and metals
    • 9.1 Organic molecules in living systems
    • 9.2 Metals and oxygen chemistry
    • 9.3 metals for nitrogen chemistry
    • 9.4 Exercises
  • 10. Chemical genetics
    • 10.1 Protein-small molecue interaction
    • 10.2 chemical genetics
    • 10.3 chemical genetics and drug developmment
    • 10.4 Exercises
  • 11. Biopharmaceuticals
    • 11.1 Introduction to Biopharmaceuticals
    • 11.2 Important biological medical products
    • 11.3 Exercises
  • 12. Synthetic Biology
    • 12.1 Synthetic Biology (1)
    • 12.2 Synthetic Biology (2)
    • 12.3 Exercises
  • Final examination

    Taught by

    YANG YU and JUN LI

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