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This conference talk from NVIDIA GTC 2025 provides a comprehensive exploration of the latest developments in NVIDIA software for high performance computing (HPC) applications. Dive into what's new in programming models, compilers, libraries, and tools specifically designed for HPC developers. The 34-minute session covers traditional HPC modeling and simulation, quantum computing, HPC+AI integration, scientific visualization, and high-performance data analytics. Presented by Becca Zandstein, Director of Product Management at NVIDIA, the talk highlights technologies including Grace CPU, CUDA, OpenACC, Hopper, cuBLAS, CUDA-X, cuFFT, NCCL, NSight Compute, and NSight Systems. Gain valuable insights into the CUDA Toolkit and other NVIDIA solutions that are advancing scientific computing and supercomputing capabilities.