Beyond Sequence - Impact of Geometric Context for RNA Property Prediction

Watch a 54-minute research presentation exploring how incorporating geometric information into RNA property prediction models can enhance their performance compared to traditional sequence-based approaches. Dive into findings from a systematic evaluation that demonstrates geometry-aware models achieve 12% better prediction accuracy across various RNA tasks, particularly excelling in scenarios with limited data availability. Learn about the trade-offs between different RNA structural representations (1D sequences, 2D topological graphs, and 3D all-atom models) and their impact on predicting RNA properties like stability and interactions. Discover insights from a newly curated RNA dataset with enhanced structural annotations, understanding how geometric context benefits RNA analysis while considering real-world challenges such as sequencing noise, partial labeling, and computational efficiency. Explore the implications for advancing biological understanding and developing RNA-based therapeutics through this comprehensive analysis of RNA modeling approaches.