Chronic Leukemias

Join this 35-minute podcast episode from Ninja Nerd where hosts Zach and Rob delve into Chronic Leukemias, providing a comprehensive exploration of their pathogenesis, clinical features, and modern treatment approaches. Learn about the differences between Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL), including the significance of BCR-ABL in CML and the importance of smudge cells and monoclonal B-cell proliferation in CLL. Discover key diagnostic methods such as PCR, flow cytometry, and blood smear analysis, alongside cutting-edge treatments including tyrosine kinase inhibitors for CML and targeted monoclonal antibody therapy for CLL. The discussion also covers disease progression, complications like Richter transformation, and treatment indications for asymptomatic patients, making this episode valuable for both exam preparation and clinical practice.