Circulating Inflammatory Biomarkers Associated with Cognitive Function and Dementia

Join a 55-minute webinar led by Dr. Margaret Doyle exploring the relationship between inflammatory biomarkers, cognitive function, and dementia. Delve into groundbreaking research utilizing the Olink proteomics inflammation panel to examine associations with cognitive testing domains and incident dementia in the Framingham Heart Study Offspring cohort. Discover how specific inflammatory proteins like TNFB and CDCP1 correlate with increased risk of all-cause and Alzheimer's disease dementia, and explore the differential effects of inflammatory markers across APOE genotypes. Learn about the distinct protein associations observed between APOE ε2 and ε4 carriers, particularly in executive function, memory, and visuospatial domains. Gain valuable insights into the role of inflammation in cognitive decline and Alzheimer's disease pathogenesis, while understanding innovative approaches to identifying crucial inflammatory biomarkers for dementia risk assessment. Dr. Doyle, an Associate Professor of Pathology and Laboratory Medicine at UVM with extensive experience in inflammatory pathway research and immune cell profiling, shares her expertise in this comprehensive examination of the intersection between inflammation and cognitive health.