Coagulopathy: Pathophysiology, Diagnosis and Treatment of Bleeding Disorders

Dive into a comprehensive lecture on Coagulopathy delivered by Professor Zach Murphy, offering a high-yield breakdown of bleeding and clotting disorders related to the coagulation cascade. Learn about the normal physiology of coagulation, including intrinsic, extrinsic, and common pathways, as well as the roles of vitamin K, calcium, and various coagulation factors. Explore both congenital coagulopathies (hemophilia A and B, von Willebrand disease) and acquired conditions (liver disease, vitamin K deficiency, anticoagulant use, DIC), with detailed explanations of their pathophysiology, laboratory findings (PT, aPTT, bleeding time), and clinical manifestations. Master the interpretation of mixing studies, patterns of lab abnormalities, and the clinical approach to evaluating bleeding patients. The lecture provides valuable comparisons of commonly tested coagulopathies for medical exams like USMLE, COMLEX, and PANCE, incorporating clinical pearls and integrative charts to reinforce understanding of these critical hemostatic abnormalities.