Mechanisms of Chromosome Folding and Gene Expression

Watch a comprehensive lecture exploring the intricate mechanisms of chromosome folding, delivered by renowned researcher Job Dekker from the Howard Hughes Medical Institute. Discover the current understanding of mammalian chromosome folding, focusing on two key mechanisms: the spatial segregation of eu- and heterochromatin through biophysical phase separation, and chromatin loop formation via loop extrusion by molecular motors like cohesin and condensin complexes. Learn how multiple loop extruding complexes work together to fold chromosomes during mitosis, and understand how cell type-specific interphase chromosome folding is inherited through mitotic division. Gain insights from Dekker's groundbreaking research, which includes the development of chromosome conformation capture methodology and studies on genome folding across various organisms, including those with unusual genome organizations like dinoflagellates.