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NPTEL

Organic Chemistry in Biology and Drug Development

NPTEL and Indian Institute of Technology, Kharagpur via YouTube

Syllabus

Organic Chemistry in Biology and Drug Development.
Lecture 1 : A brief introduction to Molecules of Life.
Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions.
Lecture 3 : Amino Acids: The building block of proteins.
Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction.
Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein.
Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods.
Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality.
Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods.
Lecture 9 : Recent development of coupling agents;.
Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure.
Lecture 11 : Ramachandran plot and protein purification techniques.
Lecture 12 : Protein Purification Techniques (Contd.).
Lecture 13 : Introduction to Enzymes and its kinetics.
Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases.
Lecture 15 : Enzyme Kinetics (Contd.).
Lecture 16 : Concept of Enzyme Inhibition.
Lecture 17 : Concept of Enzyme Inhibition (Contd.).
Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition.
Lecture 19 : Synthetic Biology.
Lecture 20 : Synthetic Biology (Contd.).
Lecture 21 : Synthetic Biology (Contd.).
Lecture 22 : Nucleic Acid.
Lecture 23 : Nucleic Acid (Contd.).
Lecture 24 : DNA sequencing method.
Lecture 25 : DNA sequencing method (Contd.).
Lecture 26 : DNA sequencing method (Contd.).
Lecture 27 : Synthesis of oligonucleotide.
Lecture 28 : Central dogma: DNA replication, transcription and translation.
Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.).
Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 33 : Molecular Biology.
Lecture 34 : Molecular Biology (Contd.).
Lecture 35 : Chemistry of cofactors/coenzymes.
Lecture 36 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 37 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 38 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 39 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 40 : Chemistry of cofactors/coenzymes (Contd.).
Lecture-41: " Introduction to Drug Discovery Process".
Lecture-42: " Fundamental Principles of Drug Development Process".
Lecture-43: " Combinatorial chemistry".
Lecture-44: "Neurotransmitters".
Lecture-45: " Catechol amine based and GABA neurotransmitters".
Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system".
Lecture-47: " Inhibitor design of angiotensin converting enzyme".
Lecture 48: Antimicrobial drugs.
Lecture 49: Chemistry of penicillins.
Lecture 50: Resistance to beta-lactam antibiotics.
Lecture 51: Mechanistic studies of beta-lactamase.
Lecture 52: Non beta-lactam antibiotics.
Lecture 53: Mechanistic enzymology of Isopenicillin N synthase.
Lecture-54 : Polyketide Biosynthesis.
Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus.
Lecture 56 : Anti-viral drugs.
Lecture-57 : Cancer and Chemotherapy.
Lecture-58 : Anti-cancer drugs (contd).
Lecture 59 : Aromatase inhibition and Anti-ulcer drugs.
Lecture-60 : Cholesterol lowering agents.
Lecture 61 : Cholesterol Biosynthesis.
Lecture-62 : Pharmakinetics and pharmadynamics.
Lecture-63 : QSAR principles.

Taught by

IIT Kharagpur July 2018

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Reviews

4.4 rating, based on 5 reviews

Start your review of Organic Chemistry in Biology and Drug Development

  • BAVANI T
    1
    The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods...
  • Vaishali
    Great information regarding the role of organic chemistry in biology and drug development. The way of explaining the relationship between the chemistry and biology and also in drug development is great. I can easily relate and understand the basics. Organic chemistry is the first step in the way of new drug development so the lectures are very very informative.
  • Profile image for Jaswanth Achari
    Jaswanth Achari
    Good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good good
  • Nishant Singla
    Overall good experience.... This indisciplinary course is useful for many chemistry aspirants and it's applications in our daily life
  • Profile image for Vyshnavi Velasiri
    Vyshnavi Velasiri
    It was a very useful session for those who are very interested in chemistry.we can learn new things beyond from our academic ones

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