Physiologically-Based and Population Pharmacokinetic Modeling in Molecular Radiotherapy

This 47-minute invited lecture by Dr. Deni Hardiansyah explores the applications of Physiologically-Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) modeling in Molecular Radiotherapy (MRT), also known as Radiopharmaceutical Therapy (RPT). Learn about the general concepts of pharmacokinetic modeling before diving into PBPK modeling fundamentals and their specific implementation in radiotherapy contexts. Discover how Population PK approaches can enhance treatment planning, followed by an examination of integrated PBPK+Population PK models for improved dosimetry in MRT. Dr. Hardiansyah, an associate professor at the University of Indonesia with a doctorate from Heidelberg University, brings extensive expertise from his research in nuclear medicine dosimetry, molecular imaging, and pharmacokinetic modeling. The lecture is organized into clear sections covering introductory concepts, modeling approaches, practical implementations, and concluding insights.