Platelet Disorders - Clinical Medicine

Dive into a comprehensive 2-hour lecture where Professor Zach Murphy from Ninja Nerd thoroughly explains platelet disorders in clinical medicine. Learn about platelet physiology, structure, and function in hemostasis before exploring both quantitative disorders (thrombocytopenia and thrombocytosis) and qualitative platelet dysfunctions. Understand the causes of thrombocytopenia including bone marrow failure, increased destruction, and sequestration, as well as the differences between reactive and clonal thrombocytosis. Master clinically significant conditions like immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), heparin-induced thrombocytopenia (HIT), and disseminated intravascular coagulation (DIC) through detailed explanations of their pathophysiology, diagnostic features, and treatment approaches. The lecture includes high-yield comparisons particularly useful for USMLE preparation, with practical clinical pearls throughout. Topics are organized in a logical progression from basic pathophysiology to clinical manifestations, diagnostic approaches, and treatment strategies for various platelet disorders.