Respiration - Part 3: Hemoglobin, Oxygen Binding, and Gas Exchange

This 29-minute lecture explores the complex mechanisms of respiration, continuing from previous parts. Delve into hemoglobin's role in oxygen transport, examining cooperative binding, the oxygen binding process, and Hill's coefficient. Learn about gas exchange at both tissue and lung levels, including the chloride shift phenomenon. Understand hemoglobin's dual function in oxygen and carbon dioxide transport, the Haldane effect, and factors affecting oxygen affinity such as temperature, pH, and structural changes. Examine the differences between fetal and adult hemoglobin through dissociation curves, and discover the significance of 2,3-diphosphoglycerate (2,3-DPG) in oxygen regulation. The lecture also covers carbaminohemoglobin formation, the dissociation of carbonic acid, and the role of anion exchanger 1 in respiratory physiology.