Spatiotemporal Modeling of Molecular Holograms

In this hour-long talk, Dr. Xiaojie Qiu from Valence Labs presents groundbreaking research on spatiotemporal modeling of molecular holograms. Explore the development and applications of Spateo, a 3D spatiotemporal modeling framework designed to quantify embryonic development dynamics. Learn how this innovative tool enables scalable, partial, non-rigid alignment, multi-slice refinement, and mesh correction to create comprehensive molecular holograms of whole embryos. Discover how Spateo digitizes multi-level biology from subcellular to whole organ scales, identifies expression gradients along orthogonal axes of 3D structures, models intercellular and intracellular interactions, and introduces "morphometric vector fields" to track cell migration. The presentation covers how these techniques bridge macroscopic changes with molecular dynamics, particularly in asymmetrical murine heart organogenesis, ultimately enabling the study of organ ecology at a molecular level in 3D space over time. Connect with the speaker and the AI for drug discovery community through the Valence Labs Portal for further discussion on this research published in Cell.