Multivalent Binding and Selectivity in Molecular Targeting, Recognition and Activation

Explore a comprehensive scientific lecture from Dr. Jure Dobnikar of the Chinese Academy of Sciences focusing on the physics of multivalent binding and its crucial applications in biological processes. Delve into the fundamental principles of selective molecular targeting, recognition, and activation in biological systems. Learn how super-selective probes utilize multivalent binding between ligands and target receptors for precise surface recognition. Discover cutting-edge research on targeting cells, detecting microbial genomes, and activating immune system responses through multicomponent receptor-covered surfaces and engineered membrane compositions. Examine how sensitivity and selectivity in genomic DNA screening methods can be enhanced through multivalent targeting, and understand the mechanisms behind receptor activation in autoimmune disorders. Gain insights into how self-assembly of macromolecular clusters and multivalent binding create specificity from non-specific electrostatic interactions, with implications for new treatment possibilities in TLR9-mediated immune responses.