ecDNA and Breakage Fusion Bridge: Two Facets of Oncogene Amplification in Cancer

Explore the mechanisms of oncogene amplification in cancer through a comprehensive lecture focusing on extrachromosomal DNA (ecDNA) and Breakage Fusion Bridge (BFB) cycles. Delve into cutting-edge research presented by Vineet Bafna at the Computational Genomics Summer Institute (CGSI) 2024. Examine the role of ecDNA in cancer development and progression, drawing insights from recent studies published in prestigious journals. Investigate the CoRAL method for accurately resolving ecDNA genome structures using long-read sequencing. Learn about the significance of ecDNA in the cancerous transformation of Barrett's oesophagus. Gain a deeper understanding of these two facets of oncogene amplification and their implications for cancer research and potential therapeutic approaches.