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Online Course

Biochemistry: Biomolecules, Methods, and Mechanisms

Massachusetts Institute of Technology via edX

134
Found in Biology, Chemistry

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Overview

Do you want to prepare for medical school, study a STEM field, become a research scientist, or transition to a career in the booming biotechnology industry? Or maybe you just want to understand the chemical reactions that govern life itself. Join Professor Yaffe, an MIT professor and practicing surgeon, as he guides you through the science that inspires countless doctors, researchers, and students alike.

We developed 7.05x Biochemistry with an emphasis on:
  • Developing your scientific thinking skills including articulating hypotheses, performing thought experiments, interpreting data, and designing experiments.
  • Using data based on real scientific experiments and highlighting the scientific process.
  • Asserting that biology is an active field that changes daily through examples of MIT (and other current) research, not static information in a textbook.
  • Visualizing real molecular structures with PyMOL to better understand function and mechanism.
  • Appreciating the quantitative aspects of biochemistry and practicing this quantitation with MATLAB.
  • Translating topics in biochemistry to diseases and medicine.  
  • Conveying the authentic MIT firehose experience.
  • Implementing the science of learning in the course design.
We offer a thorough and robust means of certifying edX learners in their mastery of the MITx biochemistry content, through the MITx 7.05x Biochemistry Competency Exam. This challenging option is available only to those who register for the verified-certificate track, and successful completion of this exam is the majority of the assessment grade that counts toward a certificate. The Competency Exam will be open from January 21, 2020 to January 28, 2020.

Syllabus

The course includes the following learning sequences:
  • Introduction to Biochemistry; pH and Buffers
  • Amino Acids and Proteins
  • Protein Purification
  • Protein Structure 
  • Protein Folding
  • Hemoglobin and Allostery
  • Hemoglobin and the Bohr Effect
  • Enzyme Chemistry
  • Enzyme as Catalysts
  • Enzyme Kinetics
  • Membranes, Channels, Transporters, and Pumps
  • Blood Clotting
  • Signal Transduction

Taught by

Michael Yaffe, Mary Ellen Wiltrout, Darcy Gordon and Monika Avello

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Reviews for edX's Biochemistry: Biomolecules, Methods, and Mechanisms Based on 13 reviews

  • 5 stars 38%
  • 4 stars 31%
  • 3 stars 23%
  • 2 star 0%
  • 1 star 8%

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  • 1
Bl C
Bl is taking this course right now.
The course overall has good coverage of the subject and engaging supplementary materials through PyMOL, MATLAB, and database usage, but the interface, assessments, discussion environment seem half-baked.

Content-wise the lectures are very informative at a good pace. Prof. Yaffe discusses the topics with great economy of words to the point that the lecture transcriptions are enough to understand the topics discussed. A simple listing of goals and objectives at the beginning of every learning sequence gives an idea of the scope.

Some of the test-yourself questions in th…
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Anonymous
Anonymous is taking this course right now.
First, the bad news: gotta agree with the MATLAB comments. Longest so-called "help" video is less than 4 minutes and even less useful. It's become a guessing game and I'm not going to keep playing it. Feedback/question answers are not timely, and typically not particularly helpful in deciphering. If it's going to be part of the course, they really should say so up front. And MIT ought to offer a MATLAB course to get people going using it. NOTE: not referring people to MATLAB's idea of educating (wanting, at best), but offering the course in a detailed way, specifically targeted in a bi…
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Anonymous
Anonymous is taking this course right now.
This is a fitting addition to the edX/MIT biology offerings (including 7.00x and the 3 7.28x courses). It is extremely comprehensive with respect to both the lectures and the testing, but one thing is always certain in these courses: if you dedicate the amount of time required, which will vary widely depending on prior knowledge, you *will* come away knowing the material. For some, this may include more detail than they want, if a high level overview is desired, but however well one does on the testing, it is a real treat to have access to a professor like Michael Yaffe, who is extraordinaril…
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Anonymous
Anonymous is taking this course right now.
I am 2/3 through this course and am thoroughly enjoying it. The lecture content is presented by Professor Yaffe in a clear and easy to follow format. The interspersed 'test yourself questions' break up the lectures nicely and help make sure I have understood topics before moving on. The problem sets are written in a fun, anecdotal way that is very engaging and helps me imagine what it would be like attending labs with students. The problem sets are not a simple regurgitation of facts, but challenge you to think critically and truly test understanding of the material. I am concurrently studying to write the MCAT and am finding the knowledge I'm learning here is definitely improving my practice testing in the Bio/Biochem section. Thanks for the opportunity!
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Anonymous
Anonymous is taking this course right now.
I started this course after taking already MITx-7.00x and MITx-7.28 1-3x and to see whether/how this course fills gaps between the other two excellent course . I appreciate the mixture of chalkboard lectures, animations, and test yourself questions. In particular, I like the introduction to PyMOL and MATLAB.

The problem sets with the characters and storyline comes close to real life situations in the lab and are challenging but doable at the same time.
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Anonymous
Anonymous is taking this course right now.
It doesnt do a good job of explaining Matlab if you are new to it. Dont take the course unless you are very comfortable with Matlab and programming in general. Since this aspect is not explained anywhere, it makes the course frustrating as you ABSOLUTELY use it to finish up graded portions. Would not have taken the course if they highlighted that MATLAB is REQUIRED
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Anonymous
Anonymous is taking this course right now.
God MATLAB is so frustrating when you do not come from a MATLAB using background. They really should note that this is NEEDED to complete various parts of the course. I will be unenrolling as I have no idea how to do ANYTHING in MATLAB and this course is really putting me off for any further Edx courses.
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Anonymous
Anonymous is taking this course right now.
This course provides a great introduction to biochemistry, which can be followed even without prior organic chemistry knowledge. There are some MATLAB coding components though, which may be a bit tricky if you haven't used the language before.
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Anonymous
Anonymous is taking this course right now.
MITx biochemistry is an excellent course, and professor Yaffe is an excellent lecturer. All parts of the course are open for audit track, including the problem sets. One drawback is that you need to know Matlab for some questions on the problem sets.
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Anonymous
Anonymous is taking this course right now.
The course is definitely challenging but you get great feedback on work. I would go in with some knowledge of MATLAB though, its not really explained well in the course.
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Anonymous
Anonymous is taking this course right now.
The course is difficult. I do not think it is an intermediate course, even though I have previous knowledge of some of the topics,although I am studying at a Greek University that has a similar content with the course. Moreover, the professor recalls meanings from other courses that the students of MIT have already done and many of them I did not know them.Last but not least, they have this MATLAB program, that they do not explain really well and they do not do a good work. As a result,I am having a really harsh time in answering many questions that require this program.
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Kareem S
Kareem is taking this course right now.
The Basics that every biochemist needs. But you need to take your time reviewing the materials, and have a good understanding of the referred chemistry subjects.

I did not finished it, so definitely going to take the re-run.
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Anonymous
Anonymous is taking this course right now.
Thank you. but I can¨t with Matlab and Pymol. There is a lot of work it´s very very interesting I have learned many things .
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