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Online Course

Molecular Biology - Part 1: DNA Replication and Repair

Massachusetts Institute of Technology via edX

(28)
1.2k
Found in Biology Courses
  • Provider edX
  • Cost Free Online Course (Audit)
  • Session Upcoming
  • Language English
  • Certificate $99 Certificate Available
  • Effort 4-6 hours a week
  • Duration 8 weeks long
  • Learn more about MOOCs

Taken this course? Share your experience with other students. Write review

Overview

You’re acquainted with your DNA, but did you know that your cells synthesize enough DNA during your lifetime to stretch a lightyear in length? How does the cellular machinery accomplish such a feat without making more mistakes than you can survive? Why isn’t the incidence of cancer even higher than it is? And, if the DNA in each and every cell is two meters long, how is this genetic material compacted to fit inside the cell nucleus without becoming a tangled mess?

Are you ready to go beyond the “what" of scientific information presented in textbooks and explore how scientists deduce the details of these molecular models?

Take a behind-the-scenes look at modern molecular genetics, from the classic experimental events that identified the proteins involved in DNA replication and repair to cutting-edge assays that apply the power of genome sequencing. Do you feel confident in your ability to design molecular biology experiments and interpret data from them? We've designed the problems in this course to build your experimental design and data analysis skills.

Let’s explore the limits of our current knowledge about the replication machinery and pathways that protect the fidelity of DNA synthesis. If you are up for the challenge, join us in 7.28x Part 1: DNA Replication and Repair.

Follow the latest news from MITx Biology @MITxBio on Twitter .

Taught by

Tania A. Baker and Stephen P. Bell

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Reviews for edX's Molecular Biology - Part 1: DNA Replication and Repair Based on 28 reviews

  • 5 stars 68%
  • 4 stars 32%
  • 3 star 0%
  • 2 star 0%
  • 1 star 0%

Did you take this course? Share your experience with other students.

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  • 1
Maximilian V
Maximilian is taking this course right now, spending 3 hours a week on it and found the course difficulty to be hard.
To put my review into context:

I hold a MSc in Agricultural sciences, working in (molecular) plant breeding.

That means: I am familiar with genetics and replication, mitosis, meiosis.

This course is of interest for me because I wanted to get behind the molecular mechanisms of all the lab-techniques I use like PCR / Sequencing to possibly improve the assays I develop or to adopt assays.

The course requires quite some attention but it is totally worth it!

It gives so much understanding on how the molecular machinery works in concert and everything is backed-up with experiments. Sometimes WAY to detailed (for me) but overall a great course.

I especially like the explanatory videos.

Really well done!

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Anonymous
Anonymous completed this course.
Very intense but extremely interesting! I loved the way not only the cool parts about the biological mechanisms were taught, but also all the assays to find out about these mechanisms. Biology has a lot of logic and I liked this clean aspect of it that MIT reveals. I'm excited for Part 2!

- Just one small remark: why can't all 3 Parts of Molecular Biology be open all the time (or most) like with 7.00x? I would have liked to continue on instead of waiting for the next part to open... (unless the course is new and I just haven't realised) :)
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Anonymous
Anonymous is taking this course right now.
Being a biology major, this course is helping me a lot regarding understanding the molecular mechanisms involved in events happening in the cell nucleus or with bacterial DNA. The better part is the exposures to different assays used in different labs. This creates a proper conceptual understanding of the assay techniques and how to troubleshoot them. Thus it is great for both theoretical studies and for being a researcher.
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Anonymous
Anonymous is taking this course right now.
I've just completed Week 3 of this 8 week course and so far I'm impressed. The lecturer, Prof Bell, is very good and I'm learning more about DNA replication than in any other course I've taken. However, this is not an introductory course in DNA replication and anyone who is new to this area is advised to learn some of the basics before venturing into this course.
Was this review helpful to you? Yes
Richard S
Richard is taking this course right now.
This course is wonderful for me. I took the MIT edX Intro Biology course, and found the lesson plan, homework and quizzes to be optimized for learning. Continuing my biology studies here has kept up the rigor in a way that really seems to trick my brain into understanding. MIT's professors really do a great job of making the subject interesting.
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Anonymous
Anonymous is taking this course right now.
This is a very good course. I withheld a star because I feel certain subjects need to be clarified more as they are explained, especially the assays. The devil is in the details when it comes to assays and every assumption needs to be made clear. Animations would be quite helpful to detail the steps...
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Maria A
Maria is taking this course right now, spending 3 hours a week on it and found the course difficulty to be medium.
It is a must sought course for those with a background in Biotechnology or other Life Sciences. Very informative and thought-provoking course.
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Javier P
Javier is taking this course right now, spending 5 hours a week on it and found the course difficulty to be medium.
The quality course is really amazing, especially the animations, that help to understand concepts that could be quite hard to grasp any other way. Even though I'm rather familiar with the subject, the course is designed so the information flows in a way that makes interesting and the expertise and teaching...
Was this review helpful to you? Yes
Anonymous
Anonymous is taking this course right now.
I find the course extremely interesting. My 2 major problems are:

First, I am a professional physicist taking the course by pure curiosity. I do understand experiments in general, but have absolutely no clue about how assays look in real life (my knowledge on biology is purely theoretical, except some gardening!). It would be very useful to describe the assays by videos rather than simply words.

Second, even though my english is OK, I am not a native english speaker. Sometimes, the wording of questions in quizzes seems ambiguous to me. I would be more confortable solving equations than trying to guess which language subleties are hidden in the question.
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Anonymous
Anonymous completed this course.
I Agree, it was intense and extremely interesting! I have to say that it wasn't easy for myself, especially as a non-native speaker person. Sometimes a passive voice produced a tricky things with the question.

I complitely agree that having a full-lenght cource would be much more intrestingly.

I'm also have to propose the idea personal message to course instructor due to the reason of privat answers.

Thank you once more for knowledge,experience and challenge.

Serg.
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Anonymous
Anonymous is taking this course right now.
I think it is great that MIT offers these courses, especially as we can not all attend the actual classes. Coming to this course with some knowledge is helpful. I am studying it for the the pure reason to know it. The lecture are good but at times confusing, one must listen very closely. The first quiz was difficult due to not knowing much about assays. The Cerego sections are a great help. So far I am learning a great deal and hope to continue to do so. Great Job!!
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Lyuba C
Lyuba is taking this course right now, spending 5 hours a week on it and found the course difficulty to be hard.
This course is definitely worth taking if you want to expand and solidify your knowledge in molecular biology. And the thing I particularly like is problem sets, because they are like detective/adventure stories you participate in personally. Also, it is nice to find some recently published REAL papers in respected journals after every unit to test newly gained understanding of the issues described. This course is challenging, informative and fun!
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Anonymous
Anonymous completed this course.
I just want to request one thing. Please, add videos for experimental assays also. Education in my place is shit. I am a zoology majo(almost completed) and I have never even seen the gel used in electrophoresis , I can't explain how left out I felt when I saw Professors Bell saying to students that you all have worked with endo/exo-nucleases and gels.

At least people like me will be able to see what experiments look like in real life. Please!
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Timofei G
Timofei completed this course, spending 6 hours a week on it and found the course difficulty to be medium.
The course represents the first part of the 728x molecular biology series created by MITx Biology.

The course is well conceived and structured: professor Steve Bell and professor Tania Baker explain very thoroughly the course subjects.

I really loved the course quizzes that present real life simulations of biology lab activities.

I strongly recommend the course (as well as the whole 728x molecular biology series) to future learners.
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Anonymous
Anonymous is taking this course right now.
I am really enjoying this course. I loved the course Intro to Biology by Eric Landers. I have a business major background, but recently developed an interest in Biology, and research. I am enjoying Dr. Bell, but because of a weak exposure to this subject, I sometimes find the quizzes a little tough.

But overall, I am having a great time learning about the replication of DNA and the various assays.

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Anonymous
Anonymous completed this course.
Very insightful course in terms of cellular function at a molecular level. It enables you to understand in a much clearer way all the basic processes that make any living organism functional.

With regards to the course methodology, I can say it is very practical and introduces concepts and new questions in a fairly oxygenated fashion, which makes it way more easier to fulfill the learning objectives.
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Anonymous
Anonymous is taking this course right now.
This class has been interesting, informative and user friendly. There are a good amount of well designed questions to test your knowledge as you go along as well as quizzes to help solidify your knowledge. Both the test yourself questions and the quizzes allow you to see the answers after you have finished which is very helpful in understanding more precisely where your knowledge gaps are.
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Anonymous
Anonymous completed this course.
I liked learning about the different assays, which will be really helpful in research carrier. Although I would have liked more of detailed mechanisms of Double strand break repair, especially for eukaryotic cases. Overall it was a great experience learning different molecular mechanisms, assays involved in finding new factors, and troubleshooting different problems which happen in lab.
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Anonymous
Anonymous is taking this course right now.
I find this course very helpful in understanding the aspects of DNA replication. As a student of biology, I need to have clear concepts about this topic and this course provides that. The end of video questions are very simple and I'd love it more if they are a little more challenging.
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Anonymous
Anonymous is taking this course right now.


The course is very well structured and the teachers' explanations are very clear, the videos about the action mechanisms are very explanatory.

I am a pharmacist and the course is increasing my knowledge in the DNA field but I find the quizzes a bit difficult.
Was this review helpful to you? Yes
  • 1

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