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Massachusetts Institute of Technology

MIT 5.07SC Biological Chemistry I, Fall 2013

Massachusetts Institute of Technology via YouTube

Syllabus

Lexicon of Biochemical Reactions: Introduction.
Lexicon of Biochemical Reactions: Cofactors Formed from Vitamin B12.
Lexicon of Biochemical Reactions: Vitamin B6 / PLP.
Lexicon of Biochemical Reactions: Redox Cofactors.
Problem Set 1, Problem 1: Sizes and Equilibria.
5. Enzymes and Catalysis.
Problem Set 2, Problem 1: Primary Structure.
Problem Set 3, Problem 2: Proteases: Mechanisms of Inhibition.
Carbonyl Chemistry.
Problem Set 4, Problem 2: The Mechanism of HMG-CoA Synthase.
Problem Set 5, Problem 5: How Mannose, an Isomer of Glucose, Enters Glycolysis.
Introduction to Carbohydrate Catabolism.
Problem Set 6, Problem 2: Mechanism of Phosphoglycerate Mutase.
Glycolysis and Early Stages of Respiration.
Respiration: TCA Cycle.
Problem Set 7, Problem 1: Tracing Labels through Pathways.
Maintenance of Redox Neutrality.
Respiration: Electron Transport and Oxidative Phosphorylation.
Problem Set 8, Problem 2: Bioenergetics of the Electron Transport Chain.
Respiration: Proton Pumps and ATP Synthesis.
Lipod Catabolism: Fatty Acid Beta-Oxidation.
Special Cases in Fatty Acid Metabolism.
Problem Set 9, Problem 1: Catabolism of Triacylglycerols.
Ketogenesis, Diabetes, and Starvation.
The Science Behind Type II Diabetes.
Blood Sugar Fluctuations and Gluconeogenesis.
When Your Breath Smells Like Nail Polish Remover.
Fatty Acids and Lipid Biosynthesis.
Carbohydrate Biosynthesis I: Glycogen Synthesis.
Carbohydrate Biosynthesis II: Gluconeogenesis.
Problem Set 10, Problem 3: Gluconeogenesis.
Pentose Phosphate Pathway.
PLP (Pyridoxal Phosphate) Reactions.
Regulation of Metabolism.

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