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Stanford University

How CRISPR Is Revolutionizing Cancer Research

Stanford University via YouTube

Overview

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This course aims to explore how CRISPR/Cas9 is revolutionizing cancer research. The learning outcomes include understanding the genetic basis of cancer, utilizing CRISPR/Cas9 for genome editing in cancer research, and identifying effective drug combinations through CRISPR screens. The course teaches skills such as inactivating genes of interest, identifying tumor suppressor genes, and assessing tumor suppression through multiplexed genome editing. The teaching method involves lectures on CRISPR/Cas9 applications in cancer research and experimental outlines for discovering gene interactions in cancer cells. The intended audience includes researchers, scientists, and healthcare professionals interested in the intersection of genetics and cancer research.

Syllabus

Introduction.
Cancer is a huge global health problem.
Some cancer types are well treated while others remain refractory to current strategies.
Cancer is fundamentally a genetic disease.
Tumors have multiple layers of genomic diversity.
CRISPR/Cas9 and many other genome editing systems exist naturally in bacterial and archaea.
Expression of Case and an SERNA in mammalian cells can inactivate a gene of interest.
Two major areas where CRISPR/Cas9-mediated genome editing has accelerated our understanding of cancer.
Libraries of SgRNAs can be used to inactivate many genes of interest in parallel.
Outline of experiment to discover pairs of genes that when inactivated kill cancer cells.
Use the information from the paired CRISPR screen to find effective drug combinations.
Two major areas where CRISPR/Cass-mediated genome editing has accelerated our understanding of cancer.
Use of CRISPR/Cas9 to understand the function of single genes of interest.
Identification of candidate tumor suppressor genes from human lung cancer sequencing data.
Multiplexed genome editing and high throughput barcode sequencing to assess tumor suppression.
Multiplexed tumor suppressor targeting leads to rapid tumor growth.
Multiplexed analysis of gene function in lung cancer in vivo helps understand tumor suppression.
Cancers often have alterations in multiple tumor suppressor genes.
Inactivation of different combinations of genes has dramatically different effects on cancer growth.
Complex functional taxonomy of tumor suppression in lung cancer NORMAL.
Personalized medicine is based on understanding how different tumors will respond to different therapies.
Multiplexed genome editing to uncover how genes impact drug responses.
Surprisingly complex map of genotype-specific therapeutic responses.
What aspects of carcinogenesis remain less well understood?.

Taught by

Stanford Online

Reviews

4.8 rating, based on 5 Class Central reviews

Start your review of How CRISPR Is Revolutionizing Cancer Research

  • I recently had the opportunity to attend the Stanford Webinar on "How CRISPR Is Revolutionizing Cancer Research," and I must say it was an enlightening experience. The webinar featured leading experts in the field of CRISPR-Cas9 technology and its…
  • Profile image for Mouna Selmani
    Mouna Selmani
    I am glad that i have attend this course. I got to know about CRISPER technology in detail and got an in depth idea about whole process. CRISPER is a great revolution in scientific field and has an immense application.
  • Rutvika Khant
    I am glad that i have attend this course. I got to know about CRISPER technology in detail and got an in depth idea about whole process. CRISPER is a great revolution in scientific field and has an immense application.
  • Ratikant Pradhan
    The video lessons were of great help in understanding the concept with a greater vertical depth at a very smooth pace. This added a lot of insights to the topic. Thankyou for such wonderful course.
  • José Escolano Signes
    very nice very nice course very nice course very nice course very nice course very nice course very nice course very nice course very nice course very nice course

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