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Swayam

Biomolecules: Structure Function in Health and Disease

All India Institute of Medical Sciences, New Delhi and CEC via Swayam

Overview

This course on Biomolecules is one of the basic course for all PG Students of Biological Sciences. This is 4 credit course. Gives an overview of importance of biomolecules starting from the simplese molecule, water. Elaborate the need to study proteins: Their 3D Structure,protein seperation,sequencing etc. To understand the pathology and identifying biomrakers using clinical proteomics. Explain in detail DNA,RNA their structures, interactions role in disease,genomics.epigenetics. Enumerate the role of carbohydrates,lipids and their cellular function in physiology and pathology. To briefly introduce to system biology

Syllabus

COURSE LAYOUT

Week 1
Chemical bonds:Different types of Bonds, Bond energies,Bond Angles etc, Water:The molecule of life,Aqueous Solution,Acids & Bases,Measurements of pH, Henderson Haselbatch equation,Titration Curve & pK values,Buffers
Week 2 Amino acids, chirality, peptide bond and polypeptides,Structural levels of proteins and Stabilizing forces,Conformational properties of polypeptides and Ramachandran plot
Week 3 Turns, loops, Super secondary structures, motifs and domains in proteins,Structures and function of Fibrous Proteins,Structure and function of Actin and myosins
Week 4 Hemoglobin, Myoglobin and Oxygen binding,Role of Protein Structure in Health and Disease,Assessment 1
Week 5 Protein Seperation Techniques: Centrifugation & Chromatography,Protein sequencing
Week 6 Methods of structure determination of proteins : X-ray, NMR, CD etc,Clinical Proteomics
Week 7 Antigen-Antibody Complex and their Applications in Immunology,Protein-Ligand(Small Molecules including drugs) interaction
Week 8 Components of Nucleic Acids,Conformational parameters of Nucleic acids and DNA double helix,DNA Polymorphism
Week 9 Circular DNA,Supercoil DNA
Week 10 Interactions of small molecules (ions, drugs ) with DNA,Different types and structures of RNA
Week 11 DNA-Protein interactions,Assessment 2
Week 12 Introduction to Carbohydrates,Structures of polysaccharides,Saturated and unsaturated fatty acids, Nomenclature of fatty acids and Essential and non-essential fatty acids
Week 13 Glycoproteins and Proteoglycons,Classification of Lipids: simple and compound lipids, phospholipids, Cholesterol,Micelles and Liposomes : Applications in biology and medicine
Week 14 Lipids: extraction, separation and analysis,Components and architecture of Cell membrane,Various membrane models including Fluid-mosaic model
Week 15 Cholesterol and its role in health and disease,Interrealtionship of Biomolecules : System Biology,Epigenetics and Human Diseases,Final Assessment

Taught by

Prof. M.R Rajeswari

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