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Drug Delivery: Principles and Engineering

Indian Institute of Technology Bangalore , NPTEL and Indian Institute of Science Bangalore via Swayam


This course introduces concepts of drug delivery to meet medical challenges. The course is designed to be modular, with each module focusing on the various aspects of drug delivery.INTENDED AUDIENCE : Anyone in bachelors having completed two yearPREREQUISITES : None. A course in biochemistry, molecular biology, anatomy is recommendedINDUSTRY SUPPORT : All pharmaceuticals, hospitals and biotechnology industries


Week 1: Pharmacokinetics: Bioavailability, Elimination, Therapeutic indexWeek 2: Prodrugs, Controlled releaseWeek 3: Polymers: Synthesis, properties, characterization, crystallinity and amorphousnessWeek 4: Biopolymers: Natural and Synthetic, biocompatibility, Biodegradation, commonly used biopolymersWeek 5: Polymer-Drug conjugates, PEGylationWeek 6: Diffusion controlled systems, Ficks laws, Reservoir systems, Non-erodible matrix systems, Bio-erodible SystemsWeek 7: Hydrogels: Physical or chemical, pore-size calculation, in-situ crosslinkingWeek 8: Nano and Micro-particles: Dendrimers, Liposomes, MicellesWeek 9: Metal and polymeric particles, effect of particle shape, charge and elasticityWeek 10: Protein Adsorption and tissue engineering, Drug delivery in tissue engineeringWeek 11: Implant associated infections, Route specific delivery: Oral, Subcutaneous, Intramuscular, transdermal, inhalation, intravenousWeek 12: Vaccines, Cancer vaccines, Cell and gene delivery, Smart responsive drug delivery, Targeted drug delivery, Nanotoxicology and market translation

Taught by

Prof. Rachit Agarwal

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