In this course, I will discuss fundamental concepts of NMR spectroscopy, experimental determination of NMR spectral parameters, their interpretation, selective and broadband homo and Heteronuclear spin decoupling, numerous examples of the analysis of NMR spectra of 1H, 13C and other heteronuclei will be given. The relaxation processes, their measurement and utility in understanding molecular dynamics, the polarization transfer mechanism, the spectral editing techniques, such as, APT, DEPT, INEPT will also be discussed. Two dimensional NMR and the commonly employed experiments, viz., COSY, TOCSY, HSQC, HMQC, HMBC, NOESY, etc will be discussed with number of examples. The practical aspects of one and two dimensional NMR data acquisition and processing will also be highlighted. The solid state NMR, magic angle spinning and cross polarization will also be discussed.INTENDED AUDIENCE :It is for chemistry students, pharmaceutical students, biology studentsPREREQUISITES :NoneINDUSTRIES SUPPORT :The pharma industries, such as, sun pharma, syngine, Biocon, Bal pharma, Aurigine, etc.
Week 1: Conceptual Understanding of NMR SpectroscopyWeek 2: NMR Spectral Parameters I (Chemical Shifts)Week 3: NMR Spectral Parameters II (Scalar and Dipolar Couplings)Week 4: Analysis of 1H NMR spectra with numerous examplesWeek 5: Selective and Broadband, Homo and Heteronuclear Decoupling, with examplesWeek 6: Analysis of NMR spectra of 13C and many other HeteronucleiWeek 7: Polarization transfer and spectral editing techniques, APT, DEPT and INEPTWeek 8: Introduction to Multi-Dimensional NMRWeek 9: Analysis of 2D COSY, TOCSY, HSQC, NOESY spectra with examplesWeek 10:Practical Aspects of obtaining high resolution NMR spectraWeek 11:Relaxation processes, their measurement and utility in understanding molecular dynamicsWeek 12:NMR in solid state, Magic Angle Spinning and Cross polarization