This introductory virology course emphasizes the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles are presented with examples drawn from a set of representative animal and human viruses, although selected bacterial viruses will be discussed.
This offering has been a top-ten iTunes U Course in sciences pretty much since its release in 2012, with over 80,000 subscriptions. The course will be ported to the Coursera platform in two parts and will allow interested online students to take the course as a cohort for the first time.
Week 1 Welcome to virology What is a virus? Viruses then and now Week 2 The infectious cycle Assay of viral infectivity Measurement
of virions and their components Revolutionary methods One-step growth
cycle Week 3 The Baltimore scheme DNA virus genomes RNA virus genomes Viral
Week 4 Structure The tools of structural virology Helical symmetry Icosahedral symmetry Enveloped virions Complex virions
Week 5 Attachment to cells Entry into cells Acid-catalyzed fusion A new paradigm for entry Entry of non-enveloped virions Entering the nucleus
Week 6 Viral RNA synthesis RNA polymerization Plus strand RNA synthesis Negative strand RNA synthesis RNA synthesis of dsRNA genomes RNA synthesis as a source of diversity
Week 7 DNA basics Lessons from SV40 Priming via DNA or protein Viral origins Big DNA viruses Regulation of DNA synthesis
Week 8 Transcription Initiation of transcription Viral transcription regulation Capping and polyadenylation Pre-mRNA splicing
Week 9 Reverse transcriptase Retroviruses Reverse transcription Integration The provirus Hepatitis B virus
Week 10 End-dependent initiation of protein synthesis Other decoding mechanisms One mRNA, one protein? Maximizing coding capacity of the viral genome Regulation of translation: eIF2alpha How viruses regulate cell translation MicroRNAs
Week 11 Principles of virion assembly Getting to the right place Making sub-assemblies Concerted assembly: Budding Genome packaging Acquisition of an envelope and egress
I am semi-retired physician and I have found Dr. Racaniello's Virology course a wonderful refresher and source of new learning. His enthusiasm is infectious and his style and explanations are thorough and understandable for a novice like myself. I supplement the learning with his TWIV podcast which I highly recommend. Thank you Dr. R.
John Smith completed this course, spending 3 hours a week on it and found the course difficulty to be hard.
This is an amazing course taught by a leading virologist who is clearly very passionate about viruses, and his passion is contagious. I didn't realize how interesting and varied viruses were until I took this class (I also recommend virology II, how viruses cause disease), and I'm now quite fond of them. Having said that, this is a challenging course. Because it involves molecular biology, there are a number of genes, acronyms, and molecules that you are required to know. Expect a little bit of frustration from that, but the class more than makes up for it.
Anonymous is taking this course right now.
It is somewhat difficult to find as a short courses alone because it is human microbiology, tiny life microorganisms which cann't be seen in our eyes except microscopes
Hello. Can you help me. When I can do it course? This is topic very interesting for me. Can you activate this course again? Thanks.