This course aims to teach participants how to identify and develop effective antibiotics. By the end of the course, learners will be able to understand the characteristics of a successful hit, create a Target Product Profile (TPP), and evaluate pharmacological properties. The course covers topics such as hit generation, mechanism of action, screening methods, lead optimization, and medicinal chemistry. The teaching method includes short talks, discussions, and practical examples. This course is intended for individuals involved in antibiotic development, microbiology, pharmacology, or medicinal chemistry.
Antibiotic Bootcamp - What Makes a Good Hit - Why and How Do You Write a TPP
American Society for Microbiology via YouTube
Overview
Syllabus
Intro
Short Talks
Discovery Strategies
Hit Generation
Mechanism of Action
Evaluate the Pharmacology
What Did You Scream
What Was Your Screening Cell
Big Pharma Sample Collection
Libraries for Hire
Fuzzy Data
False Positives
Real Positives
The Right Way
Triage
Chemist
How much money
Common structures
Pains
Rhodamine
Computational Filters
Backlash
Structure Activity Relationship
Optimization
Increasing potency
Tractable lead
Properties
The Rule of Five
Drug Like
Lipinsky Space
Bulking Up
Natural Products
Is it good enough
Lipinski defined drug
Lipinski definition of drug
Gram positive drugs
Gram negative drugs
What is gram negative antibacterial
What is a good hit
Small molecules
Property space
Hergenrother
Lipinsky Parameters
Running through an example
Optimization parameters
Pharmacokinetics
Therapeutic Index
Chemical Design
Physical Properties
Medicinal Chemistry
Taught by
American Society for Microbiology
