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Population Genetics and Evolution - I- The Mechanisms of Evolution

International Centre for Theoretical Sciences via YouTube

Overview

This course on Population Genetics and Evolution focuses on the mechanisms of evolution. The learning outcomes include gaining insight into evolutionary processes at various biological levels, understanding new methods and approaches in evolutionary biology, and exploring topics such as bacterial and viral evolution, organism-level evolution, and mechanisms/strategies of evolution. The course teaches skills such as analyzing protein folding, clonal analysis, stem-cell fate, immunology, genome evolution, and evolutionary developmental biology. The teaching method involves lectures by experts in the field, including topics like adaptation, mutation rates, biological networks, and learning as an evolutionary process. The intended audience for this course is young researchers, particularly those at the PhD and post-doctoral level with backgrounds in physical and mathematical sciences and engineering, who are working in biology or interested in doing so.

Syllabus

Start
The Long-Term Evolution Experiment LTEE on E. coli
Adaptation to citrate
The mechanisms of evolution
Simple exponential growth
The Galton-Watson GW process
Solving the GW process
The generating function
Graphical solution
The Galton-Watson process in continuous time
Generating functions
Minimal population size
The logistic function
About the Fundamental Theorem
Selection in continuous time
Measuring fitness in the LTEE
Frequency-dependent selection
Positive selection
Prisoner's dilemma in an RNA virus

Taught by

International Centre for Theoretical Sciences

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