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Prostate Cancer Genetic Risk Assessment - Webinar - Ambry Genetics

Ambry Genetics via YouTube

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Overview

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This webinar on Prostate Cancer Genetic Risk Assessment aims to educate clinicians on using genetic risk scores (GRS) and polygenic risk scores (PRS) to personalize disease risk assessment for patients. The course covers the differences between GRS and other PRS calculations, the importance of calibration with GRS, and how PRS contributes to assessing disease risk. The teaching method includes a presentation by a urology expert and a genetic counselor, discussing the application of GRS in prostate cancer risk assessment, family history evaluation, and rare pathogenic mutation information. The intended audience for this course includes healthcare professionals involved in cancer care, particularly those interested in utilizing genetic testing for personalized risk assessment and treatment planning.

Syllabus

Intro
Disclosures
Three Inherited Risk Measures
Genetic Risk Score
Does GRS Work?
Broad-sense Validity
Narrow-sense Validity
Current Clinical Practice
Hypothesis for the Need
Direct Evidence from UKB
GRS of PCa in UKB
RPMs of PCa in UKB
Association with PCa Risk/Mortality
Simple and Clean Analysis
PCa Diagnosis-free Survival
Benefits of Genetic Assessment in
Predicting Risk: PCa Screening
Rare Pathogenic Mutations (RPMs)
Consistent Evidence for HOXB13
Evidence for Prostate Cancer Susceptibility Genes
Cumulative Effects of 100 SNPs
GRS Modifies BRCA2 Effect in PCa
Predicting Prognosis: Early Stage
Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate cancer and are Associated with Early Age at Death
Predicting Therapeutic Responses: Late Stage
BRCA2 mutations and Response to Carboplatin-based Therapy
High Levels of Microsatellite instability (MSI-H) and DNA Mismatch Repair Gene (MMR) Mutations: Actionable with Anti-PD-L1 agents
Conclusions
Case Example
Management?
Surgical Specimen

Taught by

Ambry Genetics

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