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This course provides insights into the antagonistic role of histone H1 on the H3K27me3 repressive landscape over genes and telomeric repeats. The learning outcomes include understanding the interplay between histone proteins and gene regulation. The course teaches about the specific functions of histone H1 and H3K27me3 in gene expression control. The teaching method involves a presentation by Clara Richet-Bourbousse during the SEB annual Conference 2021. This course is intended for individuals interested in molecular biology, gene regulation, and chromatin structure.