This course teaches learners how to leverage evolutionary trade-offs and phage selection pressure to reduce bacterial pathogenicity. The course covers topics such as phage therapy, isolating phage candidates, genome sequencing, measuring phage host-range, and characterizing phage binding. Students will learn to identify phages that can drive antibiotic resistance and virulence trade-offs. The teaching method includes theoretical lectures and case studies. This course is intended for individuals interested in evolutionary biology, microbiology, and phage therapy research.
Leveraging Evolutionary Trade-Offs and Phage Selection Pressure to Reduce Bacterial Pathogenicity
Overview
Syllabus
Intro
Leveraging evolutionary trade-offs and phage selection pressure to reduce bacterial pathogenicity
Phage therapy: a renewed approach
Isolating phage candidates
Incorporating genome sequencing
Measuring phage host-range
Characterizing phage binding
Trade-offs WOULD benefit phage therapy
Identify phages that drive antibiotic resistance trade-offs
Determine likelihood that mutations cause trade-offs
Identify phages that drive virulence trade-offs
Trade-ups WOULD NOT benefit phage therapy
Case 1: Emergency phage therapy in human volunteer
Examining clinical samples pre- vs. post-therapy
Evolutionary prediction
Taught by
EvoEcoSeminars
