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Indian Institute of Technology, Kharagpur

Fundamentals of Protein Chemistry

Indian Institute of Technology, Kharagpur and NPTEL via Swayam


The course provides an in-depth study into protein structure and function. Building up from an understanding of amino acids and the peptide bond that form the basics of protein structure, protein folding and denaturation will be studied followed by the techniques used for protein isolation and characterization. The importance of metalloproteins and motor proteins will be followed by a discussion on membrane proteins and transport. Important aspects of enzymes, their mechanisms, kinetics and inhibition will be looked into with specific examples. The discussion on protein interactions will cover protein-ligand and protein-protein interactions. Finally some special topics in Protein Chemistry will be discussed relevant to current literature.INTENDED AUDIENCE : Undergraduate and Graduate studentsPREREQUISITES : Biochemistry


Week 1: Amino acids and the Peptide Bond

Week 2: Protein Architecture

Week 3: Protein Folding and Denaturation

Week 4: Protein isolation and characterization

Week 5: Protein-ligand interactions

Week 6: Membrane Proteins and Transport

Week 7: Enzymes and Enzyme mechanisms

Week 8: Enzyme kinetics and Enzyme inhibition

Week 9:Metalloproteins and Motor Proteins

Week 10: Protein-Protein interactions

Week 11: Protein Structure analysis

Week 12: Special Topics in Protein Chemistry


Taught by

Prof. Swagata Dasgupta

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