This course aims to provide an understanding of basic concepts in osteoporosis diagnosis and bisphosphonates. The learning outcomes include grasping the mechanisms of bisphosphonates, changes in bone architecture, and their impact on bone density and osteoporotic fractures. The course covers topics such as microcracks, subtrochanteric fractures, osteonecrosis of the jaw, and the concept of low peak bone mass. The teaching method involves a lecture format with a duration of 53 minutes. The intended audience for this course includes healthcare professionals, particularly those in the fields of internal medicine, endocrinology, and metabolism, who are involved in diagnosing and treating osteoporosis.
Osteoporosis 101: Basic Concepts in Osteoporosis Diagnosis & Biphosphonates
Mary Greeley Medical Center via YouTube
Overview
Syllabus
Intro
Objectives
But first, let's review bone turnover
Bisphosphonates- How they work
Change in bone architecture
Alendronate and bone density The FIT trial
Bisphosphonates and osteoporotic fractures
The good...
However... back to bone physiology
Microcracks
Decreased elasticity
Atypical subtrochanteric fractures Definition
Subtrochanteric fractures Epidemiology
Osteonecrosis of the jaw
Do not test too early
The concept of low peak bone mass Bone accrual
Not all T scores are the same...
"Osteopenia" is not a disease-FRAX
Back to case 1
Limit duration of exposure if possible
Can we stop bisphosphonates? FLEX trial
Changes in bone density with drug holiday
Changes in fractures with drug holiday
Who should take a drug holiday?
Back to case 2
Take home points
Taught by
Mary Greeley Medical Center
